Restoring sight in blind cavefish
نویسنده
چکیده
which sleep uni-hemispherically or bi-hemispherically depending on the context [3], captive cetaceans almost never sleep bilaterally [ ,8,9] even when they are motionless [ 0]. Unraveling how marine mammals manage the inherent tradeoff [3] between wakefulness and sleep will require the development of procedures for observing eye closure and other physiological variables, including EEG, in free-ranging animals.
منابع مشابه
Restoring eye size in Astyanax mexicanus blind cavefish embryos through modulation of the Shh and Fgf8 forebrain organising centres.
The cavefish morph of the Mexican tetra (Astyanax mexicanus) is blind at adult stage, although an eye that includes a retina and a lens develops during embryogenesis. There are, however, two major defects in cavefish eye development. One is lens apoptosis, a phenomenon that is indirectly linked to the expansion of ventral midline sonic hedgehog (Shh) expression during gastrulation and that indu...
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As a consequence of adaptation to the cave environment, the blind Mexican cavefish, Astyanax mexicanus, has evolved several cranial aberrations including changes to bone sizes, shapes and presence of numerous lateral asymmetries. Prior studies of cranial asymmetry in cavefish focused strictly on adult specimens. Thus, the extent to which these asymmetries emerge in adulthood, or earlier in the ...
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The evolutionary mechanisms responsible for the loss of eyes in cave animals are still unresolved. Hypotheses invoking natural selection or neutral mutation have been advanced to explain eye regression. Here we describe comparative molecular and developmental studies in the teleost Astyanax mexicanus that shed new light on this problem. A. mexicanus is a single species consisting of a sighted s...
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The blind cavefish Astyanax mexicanus undergoes bilateral eye degeneration during embryonic development. Despite the absence of light in the cave environment, cavefish have retained a structurally intact pineal eye. We show here that contrary to visual degeneration in the bilateral eyes, the cavefish pineal eye has conserved the ability to detect light. Larvae of two different Astyanax cavefish...
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Vision 2020 The World Heath Organization and the International Agency for the Prevention of Blindness in 1999 jointly launched “Vision 2020—the right to sight.” This ambitious programme, to eliminate unnecessary blindness and promote good vision throughout the world, includes the control of blindness in children as one of its first five priorities. Given that there are estimated to be 45 millio...
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عنوان ژورنال:
- Current Biology
دوره 18 شماره
صفحات -
تاریخ انتشار 2008